Polyethylene glycol (PEG)

PEG in Research

Polyethlene glycol (PEG), is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological research, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. In biological research, PEGs have can have many other applications, including the bioconjugation of cells into hybridomas for antibody production, vaccine or nanoparticle delivery, drug formulation and fluorescent labelling. 

Advantages of PEGS:

- High solubility.
-Neutral pH.
-Low/no immunogenicity. 
-Non-specific interactions with biochemicals.
-Highly flexible and mobile. 

PEG abbreviation table 

Abbreviation Full Name Abbreviation Full Name Abbreviation Full Name
OH Hydroxyl/alcohol SH Thiol NH2 Amine
CHO/Ald Aldehyde N3 Azide MA Methacrylate
AC/Acrl Acrylate ACA Acrylamide GA Glutaric Acid
SA Succinic Acid GAA Glutaramide Acid SAA Succinamide Acid
AA Acetic Acid PA Propionic Acid COOH Cardroxy/Acid
OtBu t-butyl ester EPO Epoxide Ald-PH Benzaldehyde
IA Iodoacetate HZ Hydrazide Mal Maleimide
NHS/SC Succinimidyl ester SCM Succinimidyl Carboxy Methyl ester SPA Succinimidyl Propionate
SBA Succinimidyl Butanoate SGA Succinimidyl Glutaramide SG Succinimidyl Glutarate ester
SS Succinimidyl Succinate ester GAS Glutaramide Succinimidyl ester SAS Succinamide Succinimidyl ester
SVA Succinimidyl valerate Tr Trityl TBA Tert-Butoxycarbonyl
TFA Trifluoroacetic acid LA Lipoic acid DBCO Dibenzocycolctyne
RB Rhodamine B Ts/Tos Tosylate NPC 4-nitrophenyl carbonate
Dansyl 5-(dimethylamino)naphthalene-1-sulfonyl FITC Fluorescein OPSS Ortho-Pyridyl disulfide
GLC2 di-Glutamic Acid GLC3 tri-Glutamic Acid DA Dopamine
DF 4-Formyl-benzamide CDI Carbonyl Imidazole FA Folic acid
DSPE 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine DMPE 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine DPPE 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine
DLPE 1,2-didodecanoyl-sn-glycero-3-phosphoethanolamine DOPE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine Gluc Glucose
Gala Galactose CLS Cholesterol PCL Polycaprolactone
PLGA Poly(lactic-co-glycoclic acid) PI Polyimide PEI Polyetherimide