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Piwi Like RNA-Mediated Gene Silencing 2 (PIWIL2) Antibody

Catalogue No: abx002215
Price: £120.00
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Piwi Like RNA-Mediated Gene Silencing 2 (PIWIL2) Antibody

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PIWIL2 Antibody is a Rabbit Polyclonal antibody against PIWIL2. PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.

Target PIWIL2
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human PIWIL2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q8TC59 (UniProt, ExPASy)
UniProt Entry Name PIWL2_HUMAN
Gene Symbol PIWIL2
GeneID 55124
KEGG hsa:55124
String 9606.ENSP00000349208
Molecular Weight Calculated MW: 105 kDa, 109 kDa
Observed MW: 115 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Piwi Like RNA-Mediated Gene Silencing 2 (PIWIL2) Antibody

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