PML Antibody

Catalogue No: abx000086
Price: £210.00
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PML Antibody

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PML Antibody is a Mouse Monoclonal antibody against PML. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Target PML
Reactivity Mouse
Origin Mouse
Host Mouse
Clonality Monoclonal
Tested Applications WB, IF/ICC
Recommended dilutions WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Recombinant protein of human PML.
Purification Affinity purified.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 97 kDa
Swiss Prot P29590
GeneID 5371
Concentration > 1 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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