Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) Antibody

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in gamma irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Target	Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human SNAI2 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O43623 (UniProt, ExPASy)
UniProt Secondary AC	B2R6P6, Q53FC1
UniProt Entry Name	SNAI2_HUMAN
Gene Symbol	SNAI2
GeneID	6591
OMIM	172800
HGNC	11094
KEGG	hsa:6591
Ensembl	ENSG00000019549
String	9606.ENSP00000380034
Molecular Weight	30 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)

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