SNAI2 Antibody is a Rabbit Polyclonal antibody against SNAI2. Slug (SNAI2) is a widely expressed transcriptional repressor and member of the Snail family of zinc finger transcription factorsSimilar to the related Snail protein, Slug binds to the E-cadherin promoter region to repress transcription during developmentThe binding of Slug to integrin promoter sequences represses integrin expression and results in reduced cell adhesionDown regulation of E-cadherin expression occurs during the epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cellsThe tumor suppressor protein p53 induces Slug expression in γ-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein PumaDeletion mutations in the corresponding Slug gene are associated with the pigmentation disorders Waardenburg Syndrome and Piebaldism, while a genetic duplication resulting in Slug overexpression is associated with a collection of congenital heart defects termed tetralogy of Fallot.
Target |
Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) |
Clonality |
Polyclonal |
Reactivity |
Human, Mouse, Rat |
Tested Applications |
ELISA, WB, IHC |
Host |
Rabbit |
Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Recombinant protein of human SNAI2. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified by affinity chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
O43623 (UniProt,
ExPASy)
|
UniProt Secondary AC |
B2R6P6, Q53FC1 |
UniProt Entry Name |
SNAI2_HUMAN |
Gene Symbol |
SNAI2 |
GeneID |
6591
|
KEGG |
hsa:6591
|
String |
9606.ENSP00000380034
|
Buffer |
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)