Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) Antibody

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Catalogue No: abx117024
Price: US$522.00
(Size: 100 µl)

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Datasheet SDS
SNAI2 Antibody is a Rabbit Polyclonal antibody against SNAI2. Slug (SNAI2) is a widely expressed transcriptional repressor and member of the Snail family of zinc finger transcription factorsSimilar to the related Snail protein, Slug binds to the E-cadherin promoter region to repress transcription during developmentThe binding of Slug to integrin promoter sequences represses integrin expression and results in reduced cell adhesionDown regulation of E-cadherin expression occurs during the epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cellsThe tumor suppressor protein p53 induces Slug expression in γ-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein PumaDeletion mutations in the corresponding Slug gene are associated with the pigmentation disorders Waardenburg Syndrome and Piebaldism, while a genetic duplication resulting in Slug overexpression is associated with a collection of congenital heart defects termed tetralogy of Fallot.

Target Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human SNAI2.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O43623 (UniProt, ExPASy)
UniProt Secondary AC B2R6P6, Q53FC1
UniProt Entry Name SNAI2_HUMAN
Gene Symbol SNAI2
GeneID 6591
KEGG hsa:6591
String 9606.ENSP00000380034
Buffer PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)


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