Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Antibody

Catalogue No: abx001201
Price: £260.00
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PTPN11 Antibody is a Rabbit Polyclonal antibody against PTPN11. PTPN11(protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism(PMID:19017799). Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions(PMID:21576358). Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1), Noonan syndrome type 1 (NS1), juvenile myelomonocytic leukemia (JMML) and metachondromatosis (MC). It has 3 isoforms produced by alternative splicing. This antibody is specific to PTPN11.

Target PTPN11
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC, FCM
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PTPN11.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC Q06124 (UniProt, ExPASy)
UniProt Secondary AC A8K1D9, Q96HD7
UniProt Entry Name PTN11_HUMAN
Gene Symbol PTPN11
GeneID 5781
String 9606.ENSP00000340944
Molecular Weight Calculated MW: 52 kDa, 68 kDa
Observed MW: 68 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Antibody

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