Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) S1 Protein is a recombinant protein expressed in Mammalian cells.
The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the S1 and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.
| Target |
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) S1 Protein |
| Origin |
Virus |
| Expression |
Recombinant |
| Tested Applications |
ELISA, SDS-PAGE, WB |
| Host |
Mammalian cells |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Form |
Liquid |
| Purity |
> 95% (SDS-PAGE) |
| Purification |
0.2 µm filtered. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| NCBI Accession |
QHD43416.1
|
| Sequence Fragment |
Val16-Arg685 |
| Sequence |
VNLTTRTQLP PAYTNSFTRG VYYPDKVFRS SVLHSTQDLF LPFFSNVTWF HAIHVSGTNG TKRFDNPVLP FNDGVYFAST EKSNIIRGWI FGTTLDSKTQ SLLIVNNATN VVIKVCEFQF CNDPFLGVYY HKNNKSWMES EFRVYSSANN CTFEYVSQPF LMDLEGKQGN FKNLREFVFK NIDGYFKIYS KHTPINLVRD LPQGFSALEP LVDLPIGINI TRFQTLLALH RSYLTPGDSS SGWTAGAAAY YVGYLQPRTF LLKYNENGTI TDAVDCALDP LSETKCTLKS FTVEKGIYQT SNFRVQPTES IVRFPNITNL CPFGEVFNAT RFASVYAWNR KRISNCVADY SVLYNSASFS TFKCYGVSPT KLNDLCFTNV YADSFVIRGD EVRQIAPGQT GKIADYNYKL PDDFTGCVIA WNSNNLDSKV GGNYNYLYRL FRKSNLKPFE RDISTEIYQA GSTPCNGVEG FNCYFPLQSY GFQPTNGVGY QPYRVVVLSF ELLHAPATVC GPKKSTNLVK NKCVNFNFNG LTGTGVLTES NKKFLPFQQF GRDIADTTDA VRDPQTLEIL DITPCSFGGV SVITPGTNTS NQVAVLYQDV NCTEVPVAIH ADQLTPTWRV YSTGSNVFQT RAGCLIGAEH VNNSYECDIP IGAGICASYQ TQTNSPRRAR HHHHHH |
| Tag |
C-terminal 6x His-tag. |
| Buffer |
PBS, pH 7.4. |
| Endotoxin Level |
< 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on SARS-CoV-2/COVID-19 S1 Protein
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