P-Selectin Glycoprotein Ligand 1 (SELPLG) Antibody

Catalogue No: abx001395
Price: £120.00
(Size: 20 µl)
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SELPLG Antibody is a Rabbit Polyclonal antibody against SELPLG. This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].

Target P-Selectin Glycoprotein Ligand 1 (SELPLG)
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human SELPLG.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q14242 (UniProt, ExPASy)
UniProt Secondary AC A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q6GTW7, Q8N7J7
UniProt Entry Name SELPL_HUMAN
Gene Symbol SELPLG
GeneID 6404
KEGG hsa:6404
String 9606.ENSP00000228463
Molecular Weight Calculated MW: 43 kDa, 44 kDa
Observed MW: 52 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on P-Selectin Glycoprotein Ligand 1 (SELPLG)

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