P-Selectin Glycoprotein Ligand 1 (SELPLG) Antibody

SELPLG Antibody is a Rabbit Polyclonal antibody against SELPLG. This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].

Target	P-Selectin Glycoprotein Ligand 1 (SELPLG)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 348-412 of human CD162/PSGL-1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14242 (UniProt, ExPASy)
UniProt Secondary AC	A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q6GTW7, Q8N7J7
UniProt Entry Name	SELPL_HUMAN
Gene Symbol	SELPLG
GeneID	6404
NCBI Accession	NP_002997.2
KEGG	hsa:6404
String	9606.ENSP00000228463
Molecular Weight	Calculated MW: 43 kDa Observed MW: 120 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on P-Selectin Glycoprotein Ligand 1 (SELPLG)

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