P-Selectin Glycoprotein Ligand 1 (SELPLG) Antibody

SELPLG Antibody is a Rabbit Polyclonal antibody against SELPLG. This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytesAs such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectinsThis protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activityAberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune responseAlternate splicing results in multiple transcript variants.

Target	P-Selectin Glycoprotein Ligand 1 (SELPLG)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein of human SELPLG.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14242 (UniProt, ExPASy)
UniProt Secondary AC	A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q6GTW7, Q8N7J7
UniProt Entry Name	SELPL_HUMAN
Gene Symbol	SELPLG
GeneID	6404
KEGG	hsa:6404
String	9606.ENSP00000228463
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on P-Selectin Glycoprotein Ligand 1 (SELPLG)

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