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Signal Transducer And Activator of Transcription 2 (STAT2) Antibody

Catalogue No: abx000895
Price: £260.00
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STAT2 Antibody is a Rabbit Polyclonal antibody against STAT2. STAT2, also named as p113, belongs to the transcription factor STAT family. It is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. It also interacts with CRSP2, CRSP6, Simian virus 5 protein V, rabies virus phosphoprotein, IFNAR1 and IFNAR2. Its interaction with dengue virus NS5 inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), STAT2 is targeted for degradation. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human STAT2.

Target STAT2
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human STAT2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC P52630 (UniProt, ExPASy)
UniProt Secondary AC B4DLC7, G3V2M6, Q16430, Q16431, Q9UDL4
UniProt Entry Name STAT2_HUMAN
Gene Symbol STAT2
GeneID 6773
KEGG hsa:677
String 9606.ENSP00000315768
Molecular Weight Calculated MW: 97 kDa
Observed MW: 127 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Signal Transducer And Activator of Transcription 2 (STAT2) Antibody

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