Thymine DNA Glycosylase (TDG) Antibody
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Price:
US$203.00
(Size: 20 µl)
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TDG Antibody is a Rabbit Polyclonal antibody against TDG. In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. G/T mismatch-specific Thymine DNA Glycosylase (TDG) is a nuclear protein which corrects G/T mismatches to G/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymine. TDG also corrects a subset of G/U mispairs inefficiently removed by the more abundant uracil glycosylases. Retinoic acid receptors interact physically and functionally with TDG, enhancing the ability of the retinoid X receptor and the retinoid X receptor/retinoid acid receptor complex to bind to their response elements. TDG interacts with, and is covalently modified by, the ubiquitin-like proteins SUMO-1 and SUMO-2/3, resulting in a reduction of the DNA substrate and AP site binding affinity of TDG. This sumoylation is associated with a significant increase in enzymatic turnover in reactions with a G/U substrate and the loss of G/T processing activity.
Target |
Thymine DNA Glycosylase (TDG) |
Clonality |
Polyclonal |
Reactivity |
Mouse, Rat |
Tested Applications |
WB |
Host |
Rabbit |
Recommended dilutions |
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TDG. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified by affinity chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q13569 (UniProt,
ExPASy)
|
UniProt Secondary AC |
Q8IUZ6, Q8IZM3 |
UniProt Entry Name |
TDG_HUMAN |
Gene Symbol |
TDG |
GeneID |
6996
|
NCBI Accession |
NP_003202.3
|
KEGG |
hsa:6996
|
String |
9606.ENSP00000376611
|
Molecular Weight |
Calculated MW: 46 kDa Observed MW: 60 kDa |
Buffer |
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
Concentration |
> 0.2 mg/ml |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Thymine DNA Glycosylase (TDG)