TrkA (pY791) Antibody

TrkA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TrkA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

Target	TrkA (pY791)
Clonality	Polyclonal
Target Modification	Tyr791
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, WB, DB
Host	Rabbit
Recommended dilutions	WB: 1/1000, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y791 of human TrkA.
Isotype	IgG
Form	Liquid
Purification	Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04629 (UniProt, ExPASy)
UniProt Entry Name	NTRK1_HUMAN
KEGG	hsa:4914
String	9606.ENSP00000431418
Molecular Weight	Calculated MW: 87.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TrkA (pY791)

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