GP145-TrkC (TrkC) Antibody

TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

Target	GP145-TrkC (TrkC)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	His-tagged recombinant human TrkC.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q16288 (UniProt, ExPASy)
UniProt Secondary AC	B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16289
UniProt Entry Name	NTRK3_HUMAN
NCBI Accession	NP_001012338.1 NP_002521.2
KEGG	hsa:4916
String	9606.ENSP00000354207
Molecular Weight	Calculated MW: 94.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on GP145-TrkC (TrkC)

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