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Ubiquitin Carboxyl-Terminal Hydrolase 25 (USP25) Antibody

Catalogue No: abx001257
Price: £260.00
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USP25 Antibody is a Rabbit Polyclonal antibody against USP25. The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP25 (ubiquitin specific peptidase 25), also known as USP21, is a 1087 amino acid member of the peptidase C19 family. Expressed at high amounts in pancreas, kidney, skeletal muscle, testis, liver, heart, brain and lung, USP25 associates with the 26S proteasome and functions as a deubiquitinating enzyme in the Ub proteolytic pathway. Due to alternative splicing events, USP25 is expressed as two short, ubiquitously expressed isoforms and one long, muscle-specific isoform. The long isoform of USP25 is upregulated in myogenesis and is implicated in the pathogenesis of severe myopathies.

Target USP25
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein of human USP25.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at 2°C to 8°C upon receipt.
UniProt Primary AC Q9UHP3 (UniProt, ExPASy)
UniProt Secondary AC C0LSZ0, Q6DHZ9, Q9H9W1
UniProt Entry Name UBP25_HUMAN
Gene Symbol USP25
GeneID 29761
String 9606.ENSP00000383044
Molecular Weight Calculated MW: 122 kDa, 125 kDa, 129 kDa
Observed MW: 122 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Ubiquitin Carboxyl-Terminal Hydrolase 25 (USP25) Antibody

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