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Ataxin 1 (ATXN1) Antibody
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Catalogue No: abx010425
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US$427.75
(Size: 100 µl)
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Datasheet SDS
ataxin-1 is a spinocerebellar ataxia type 1 (SCA1) protein. Expansion of CAG repeats in the SCA1 gene results in an abnormally long polyglutamine tract in the protein, causing polyglutamine-induced neurodegeneration. 14-3-3 and Akt kinase stabilize both wild-type and mutant forms of ataxin-1. The expansion of the polyglutamine tract may alter this function.
Research Articles on Ataxin 1 (ATXN1)
| Target | Ataxin 1 (ATXN1) |
| Research Area | Signal Transduction |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ATXN1 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P54253 (UniProt, ExPASy) |
| UniProt Secondary AC | Q17S02, Q9UJG2, Q9Y4J1 |
| UniProt Entry Name | ATX1_HUMAN |
| Gene Symbol | ATXN1 |
| GeneID | 6310 |
| OMIM | 164400 |
| HGNC | 10548 |
| KEGG | hsa:6310 |
| Ensembl | ENSG00000124788 |
| String | 9606.ENSP00000244769 |
| Molecular Weight | 87 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |