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Caspase 3 (CASP3) Antibody
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Catalogue No: abx034999
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, 7 and 9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Research Articles on Caspase 3 (CASP3)
| Target | Caspase 3 (CASP3) |
| Research Area | Signal Transduction, Enzymes and Kinases, Apoptosis, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified His-tagged Human CASP3 protein |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P42574 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5M2, D3DP53, Q96AN1, Q96KP2 |
| UniProt Entry Name | CASP3_HUMAN |
| NCBI Accession | NP_004337.2 NP_116786.1 |
| KEGG | hsa:836 |
| String | 9606.ENSP00000311032 |
| Molecular Weight | Calculated MW: 31.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |