E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
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Catalogue No: abx034055
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(Size: 80 µl)
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Datasheet SDS
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. It also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. It may also be involved in EGFR ubiquitination and internalization.
Research Articles on E3 Ubiquitin-Protein Ligase CBL-B (CBLB)
| Target | E3 Ubiquitin-Protein Ligase CBL-B (CBLB) |
| Clonality | Polyclonal |
| Reactivity | Rat |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 103-130 amino acids from the Central region of human CBLB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13191 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K9S7, B7WNM4, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5 |
| UniProt Entry Name | CBLB_HUMAN |
| Gene Symbol | CBLB |
| GeneID | 868 |
| OMIM | 604491 |
| HGNC | 1542 |
| KEGG | hsa:868 |
| Ensembl | ENSG00000114423 |
| String | 9606.ENSP00000264122 |
| Molecular Weight | Calculated MW: 109 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Xenopus CBLB. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |