Integrin Beta 2 (ITGB2) Antibody
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Catalogue No: abx010515
Price:
US$427.75
(Size: 100 µl)
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Datasheet SDS
CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
Research Articles on Integrin Beta 2 (ITGB2)
| Target | Integrin Beta 2 (ITGB2) |
| Research Area | Signal Transduction, Cellular Differentiation and Adhesion, Tumor Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of CD18 expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P05107 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KTS8, D3DSM1, Q16418, Q53HS5, Q9UD72 |
| UniProt Entry Name | ITB2_HUMAN |
| GeneID | 3689 |
| KEGG | hsa:3689 |
| String | 9606.ENSP00000380948 |
| Molecular Weight | 85 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |