Myeloid Cell Surface Antigen CD33 (CD33) Antibody
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Catalogue No: abx015799
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells.Preferentially binds to alpha-2,6-linked sialic acid.The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules.Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD).
Research Articles on Myeloid Cell Surface Antigen CD33 (CD33)
| Target | Myeloid Cell Surface Antigen CD33 (CD33) |
| Research Area | Cellular Differentiation and Adhesion, Hematology |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P20138 (UniProt, ExPASy) |
| UniProt Secondary AC | B4E3P8, C9JEN7, F8WAL2, Q8TD24 |
| UniProt Entry Name | CD33_HUMAN |
| Gene Symbol | CD33 |
| GeneID | 945 |
| OMIM | 159590 |
| HGNC | 1659 |
| KEGG | hsa:945 |
| Ensembl | ENSG00000105383 |
| String | 9606.ENSP00000262262 |
| Molecular Weight | 39.8 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |