Gap Junction Alpha-8 Protein / CX50 (GJA8) Antibody

GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.

Target	Gap Junction Alpha-8 Protein / CX50 (GJA8)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 99-130 amino acids from the N-terminal region of human Connexin 50.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48165 (UniProt, ExPASy)
UniProt Secondary AC	A7L5M5, Q5VVN9, Q9NP25
UniProt Entry Name	CXA8_HUMAN
NCBI Accession	NP_005258.2
KEGG	hsa:2703
String	9606.ENSP00000358238
Molecular Weight	Calculated MW: 48.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Gap Junction Alpha-8 Protein / CX50 (GJA8)

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