Cleavage And Polyadenylation Specificity Factor Subunit 4 (CPSF4) Antibody
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Catalogue No: abx034444
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Inhibition of the nuclear export of poly (A) containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
Research Articles on Cleavage And Polyadenylation Specificity Factor Subunit 4 (CPSF4)
| Target | Cleavage And Polyadenylation Specificity Factor Subunit 4 (CPSF4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 96-123 amino acids from the Central region of human CPSF4. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O95639 (UniProt, ExPASy) |
| UniProt Secondary AC | D6W5S8, Q6FGE6, Q86TF8, Q9BTW6 |
| UniProt Entry Name | CPSF4_HUMAN |
| Gene Symbol | CPSF4 |
| KEGG | hsa:10898 |
| String | 9606.ENSP00000292476 |
| Molecular Weight | Calculated MW: 30.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat, Cow and Xenopus CPSF4. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |