Tyrosine-Protein Kinase CSK (CSK) Antibody
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Catalogue No: abx000843
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US$348.00
(Size: 60 µl)
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Datasheet SDS
CSK Antibody is a Rabbit Polyclonal antibody against CSK. CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration(PMID:23548896). Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells(PMID:23139636). This protein can be autophosphorylated(PMID:11181701). This antibody is specific to CSK.
Research Articles on Tyrosine-Protein Kinase CSK (CSK)
| Target | Tyrosine-Protein Kinase CSK (CSK) |
| Research Area | Enzymes and Kinases, Metabolic Pathways, Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human CSK |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P41240 (UniProt, ExPASy) |
| UniProt Secondary AC | Q2M3N2, Q6FGZ6 |
| UniProt Entry Name | CSK_HUMAN |
| Gene Symbol | CSK |
| GeneID | 1445 |
| NCBI Accession | NP_001120662.1 |
| KEGG | hsa:1445 |
| String | 9606.ENSP00000220003 |
| Molecular Weight | Calculated MW: 50 kDa Observed MW: 50 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
