Defensin Alpha 1, Neutrophil (DEFA1) Antibody
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Catalogue No: abx005247
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US$217.50
(Size: 20 µl)
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Datasheet SDS
DEFA1 Antibody is a Rabbit Polyclonal antibody against DEFA1. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Research Articles on Defensin Alpha 1, Neutrophil (DEFA1)
| Target | Defensin Alpha 1, Neutrophil (DEFA1) |
| Research Area | Infection Immunity, Dermatology |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to DEFA1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P59665 (UniProt, ExPASy) |
| UniProt Secondary AC | P11479, Q14125, Q6EZF6 |
| UniProt Entry Name | DEF1_HUMAN |
| Gene Symbol | DEFA1 |
| GeneID | 1667 |
| NCBI Accession | NP_004075.1 |
| KEGG | hsa:1667 hsa:728358 |
| String | 9606.ENSP00000372139 |
| Molecular Weight | Calculated MW: 10 kDa Observed MW: 10 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |