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DNA Methyltransferase 3 Alpha (Dnmt3a) Antibody
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Catalogue No: abx025680
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Research Articles on DNA Methyltransferase 3 Alpha (Dnmt3a)
| Target | DNA Methyltransferase 3 Alpha (Dnmt3a) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 457-486 amino acids from human Dnmt3a. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9Y6K1 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9 |
| UniProt Entry Name | DNM3A_HUMAN |
| NCBI Accession | NP_072046.2 NP_715640.2 NP_783328.1 NP_783329.1 |
| String | 9606.ENSP00000264709 |
| Molecular Weight | Calculated MW: 102 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Chicken DNMT3A. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |