Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody
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Catalogue No: abx033544
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US$326.25
(Size: 80 µl)
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Datasheet SDS
ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An Interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues.
Research Articles on Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)
| Target | Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) |
| Research Area | Signal Transduction, Tumor Immunity, Reproductive Science, Hepatology, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 21-52 amino acids from the N-terminal region of human ERBB2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04626 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RZG3, B4DHN3, Q14256, Q6LDV1, Q9UMK4, X5D2V5 |
| UniProt Entry Name | ERBB2_HUMAN |
| NCBI Accession | NP_001005862.1 NP_004439.2 |
| KEGG | hsa:2064 |
| String | 9606.ENSP00000269571 |
| Molecular Weight | Calculated MW: 138 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat ERBB2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |