DNA Excision Repair Protein ERCC-1 (ERCC1) Antibody
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Catalogue No: abx004041
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US$217.50
(Size: 20 µl)
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Datasheet SDS
ERCC1 Antibody is a Rabbit Polyclonal antibody against ERCC1. The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Research Articles on DNA Excision Repair Protein ERCC-1 (ERCC1)
| Target | DNA Excision Repair Protein ERCC-1 (ERCC1) |
| Research Area | Cellular Differentiation and Adhesion |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to ERCC1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P07992 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RC01, B3KRR0, Q7Z7F5, Q96S40 |
| UniProt Entry Name | ERCC1_HUMAN |
| Gene Symbol | ERCC1 |
| GeneID | 2067 |
| NCBI Accession | NP_973730.1 |
| KEGG | hsa:2067 |
| String | 9606.ENSP00000013807 |
| Molecular Weight | Calculated MW: 33 kDa Observed MW: 39 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |