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Coagulation Factor VIII (F8) Antibody
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Catalogue No: abx015745
Price:
US$427.75
(Size: 100 µl)
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Datasheet SDS
F8, coagulation factor VIII, procoagulant component.This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa.This gene produces two alternatively spliced transcripts.Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex.This protein undergoes multiple cleavage events.Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc.This binding domain is essential for coagulant activity.Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Research Articles on Coagulation Factor VIII (F8)
| Target | Coagulation Factor VIII (F8) |
| Research Area | Signal Transduction, Developmental Science, Bone Metabolism |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of F8 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P00451 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14286, Q5HY69 |
| UniProt Entry Name | FA8_HUMAN |
| Gene Symbol | F8 |
| GeneID | 2157 |
| OMIM | 134500 |
| HGNC | 3546 |
| KEGG | hsa:2157 |
| Ensembl | ENSG00000185010 |
| String | 9606.ENSP00000353393 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |