FYVE, RhoGEF And PH Domain-Containing Protein 4 (FGD4) Antibody
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Catalogue No: abx027128
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US$326.25
(Size: 80 µl)
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Datasheet SDS
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq].
Research Articles on FYVE, RhoGEF And PH Domain-Containing Protein 4 (FGD4)
| Target | FYVE, RhoGEF And PH Domain-Containing Protein 4 (FGD4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human FGD4. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q96M96 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6ULS2, Q8TCP6 |
| UniProt Entry Name | FGD4_HUMAN |
| Gene Symbol | FGD4 |
| KEGG | hsa:121512 |
| String | 9606.ENSP00000394487 |
| Molecular Weight | Calculated MW: 86.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |