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Gap Junction Alpha-3 Protein / CX46 (GJA3) Antibody
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Catalogue No: abx028497
Price:
US$326.25
(Size: 80 µl)
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Gap Junction Alpha-3 Protein / CX46 (GJA3), an integral membrane protein, belong to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and nonjunctional ('hemi-') channels. Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3), a form of autosomal dominant congenital cataract.
Research Articles on Gap Junction Alpha-3 Protein / CX46 (GJA3)
| Target | Gap Junction Alpha-3 Protein / CX46 (GJA3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 108-139 amino acids from the N-terminal region of human GJA3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y6H8 (UniProt, ExPASy) |
| UniProt Secondary AC | Q0VAB7, Q9H537 |
| UniProt Entry Name | CXA3_HUMAN |
| Gene Symbol | GJA3 |
| GeneID | 2700 |
| OMIM | 121015 |
| HGNC | 4277 |
| KEGG | hsa:2700 |
| Ensembl | ENSG00000121743 |
| String | 9606.ENSP00000241125 |
| Molecular Weight | Calculated MW: 47.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |