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Gonadotropin Releasing Hormone Receptor (GNRHR) Antibody
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Catalogue No: abx030196
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US$326.25
(Size: 80 µl)
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Datasheet SDS
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
Research Articles on Gonadotropin Releasing Hormone Receptor (GNRHR)
| Target | Gonadotropin Releasing Hormone Receptor (GNRHR) |
| Research Area | Signal Transduction, Tumor Immunity, Endocrinology, Reproductive Science, Hormone Metabolism, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human GNRHR. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P30968 (UniProt, ExPASy) |
| UniProt Secondary AC | O75793, Q14D13, Q92644 |
| UniProt Entry Name | GNRHR_HUMAN |
| Gene Symbol | GNRHR |
| KEGG | hsa:2798 |
| String | 9606.ENSP00000226413 |
| Molecular Weight | Calculated MW: 37.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |