Jumonji/ARID Domain-Containing Protein 1B (JARID1B) Antibody
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Catalogue No: abx028081
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Research Articles on Jumonji/ARID Domain-Containing Protein 1B (JARID1B)
| Target | Jumonji/ARID Domain-Containing Protein 1B (JARID1B) |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 192-224 amino acids from the N-terminal region of human JARID1B. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9UGL1 (UniProt, ExPASy) |
| UniProt Secondary AC | O95811, Q15752, Q9Y3Q5 |
| UniProt Entry Name | KDM5B_HUMAN |
| Gene Symbol | KDM5B |
| String | 9606.ENSP00000356234 |
| Molecular Weight | Calculated MW: 176 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |