Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody
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Catalogue No: abx137322
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US$261.00
(Size: 5 µg)
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Datasheet SDS
Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody is a Mouse Monoclonal against Lys-63-Specific Deubiquitinase BRCC36 (BRCC3). This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Research Articles on Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)
| Target | Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Host | Mouse |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Storage | Store at 4°C for up to 4 weeks. For long-term storage, aliquot and store at -20°C. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P46736 (UniProt, ExPASy) |
| UniProt Secondary AC | A6QRF8, A6QRF9, A8MUX5, A8MWH0, A9Z1Y0, A9Z1Y5, B1B062, B4DQN7, Q16107, Q53YX5, Q9BTZ6 |
| UniProt Entry Name | BRCC3_HUMAN |
| Gene Symbol | BRCC3 |
| GeneID | 79184 |
| OMIM | 300617 |
| NCBI Accession | NP_001018065.1 NM_001018055.2 [P46736-2] NP_001229569.1 NM_001242640.1 [P46736-3] NP_077308.1 NM_024332.3 [P46736-1] XP_016885327.1 XM_017029838.1 [P46736-2] |
| HGNC | 24185 |
| KEGG | hsa:79184 |
| Ensembl | ENSG00000185515 |
| String | 9606.ENSP00000358474 |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |