Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Antibody
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Catalogue No: abx015916
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family.This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli.It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3.This kinase is phosphorylated, and thus activated by MAP3K1/MEKK.The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle.It is also widely expressed in other tissues.
Research Articles on Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4)
| Target | Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) |
| Research Area | Developmental Science, Bone Metabolism |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human MAP2K4 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P45985 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R7N7, B3KYB2, D3DTS5, Q5U0B8, Q6FHX4, Q6P9H2, Q6PIE6 |
| UniProt Entry Name | MP2K4_HUMAN |
| Gene Symbol | MAP2K4 |
| GeneID | 6416 |
| OMIM | 601335 |
| HGNC | 6844 |
| KEGG | hsa:6416 |
| Ensembl | ENSG00000065559 |
| String | 9606.ENSP00000410402 |
| Molecular Weight | 42 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |