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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Antibody
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Catalogue No: abx016036
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US$427.75
(Size: 100 µl)
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Datasheet SDS
MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4.The protein encoded by this gene is a member of the serine/threonine protein kinase family.This kinase has been shown to specifically activate MAPK8/JNK.The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway.Alternatively spliced transcript variants encoding different isoforms have been identified.
Research Articles on Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4)
| Target | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O95819 (UniProt, ExPASy) |
| UniProt Secondary AC | E7ESS2, O75172, Q9NST7 |
| UniProt Entry Name | M4K4_HUMAN |
| Gene Symbol | MAP4K4 |
| GeneID | 9448 |
| OMIM | 604666 |
| HGNC | 6866 |
| KEGG | hsa:9448 |
| Ensembl | ENSG00000071054 |
| String | 9606.ENSP00000343658 |
| Enzyme Commission Number | EC 2.7.11.1 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |