Mitogen-Activated Protein Kinase 14 Phospho-Tyr322 (MAPK14 pY322) Antibody

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Catalogue No: abx000137
Price: US$232.00
(Size: 20 µl)

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Datasheet SDS
MAPK14 (pY322) Antibody is a Rabbit Polyclonal antibody against MAPK14 (pY322). The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Target Mitogen-Activated Protein Kinase 14 Phospho-Tyr322 (MAPK14 pY322)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic phosphorylated peptide around Y322 of human p38 MAPK.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q16539 (UniProt, ExPASy)
UniProt Entry Name MK14_HUMAN
Gene Symbol MAPK14
GeneID 1432
NCBI Accession NP_620581.1
KEGG hsa:1432
String 9606.ENSP00000229795
Molecular Weight Calculated MW: 41 kDa
Observed MW: 41 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Mitogen-Activated Protein Kinase 14 Phospho-Tyr322 (MAPK14 pY322)


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