Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) Antibody
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Catalogue No: abx033440
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US$326.25
(Size: 80 µl)
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Datasheet SDS
MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
Research Articles on Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7)
| Target | Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) |
| Research Area | Signal Transduction, Enzymes and Kinases, Tumor Immunity, Infection Immunity, Developmental Science, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 776-805 amino acids from the C-terminal region of human MAPK7. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13164 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51 |
| UniProt Entry Name | MK07_HUMAN |
| KEGG | hsa:5598 |
| String | 9606.ENSP00000311005 |
| Molecular Weight | Calculated MW: 88.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat and Cow MAPK7. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |