Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) Antibody
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Catalogue No: abx001723
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US$348.00
(Size: 60 µl)
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Datasheet SDS
MAPK7 Antibody is a Rabbit Polyclonal antibody against MAPK7. ERK5 (Mitogen-activated protein kinase 7, Big mitogen-activated protein kinase 1) is a member of the MAPK superfamily implicated in the regulation numerous cellular processes including proliferation, differentiation, and survival (1,5-7). Like other MAPK family members, ERK5 contains a canonical activation loop TEY motif (Thr218/Tyr220) which is specifically phosphorylated by MAP2K5 (MEK5) in a growth factor-dependent, Ras-independent mechanism (2-4). For example, EGF stimulation promotes ERK5 phosphorylation which induces its traslocation to the nucleus where it phosphorylates MEF2C and other transcriptional targets (2,3). ERK5 is also activated in response to granulocyte colony-stimulating factor (G-CSF) in hematopoetic progenitor cells where it promotes survival and proliferation (4). In neuronal cells, ERK5 is required for NGF-induced neurite outgrowth, neuronal homeostatis, and survival (11,12). ERK5 is thought to play a role in blood vessel integrity via maintainence of endothelial cell migration and barrier function (8-10). Although broadly expressed, research studies have shown that mice lacking erk5 display numerous cardiac defects, suggesting ERK5 plays a critical role in vascular development and homeostasis (1,5).
Research Articles on Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7)
| Target | Mitogen-Activated Protein Kinase 7 / ERK5 (MAPK7) |
| Research Area | Signal Transduction, Enzymes and Kinases, Tumor Immunity, Infection Immunity, Developmental Science, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human MAPK7 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13164 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51 |
| UniProt Entry Name | MK07_HUMAN |
| Gene Symbol | MAPK7 |
| GeneID | 5598 |
| NCBI Accession | NP_002740.2 |
| KEGG | hsa:5598 |
| String | 9606.ENSP00000311005 |
| Molecular Weight | Calculated MW: 50 kDa/59 kDa/73 kDa/88 kDa Observed MW: 50 kDa/80 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
