Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3) Antibody
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Catalogue No: abx011406
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Research Articles on Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3)
| Target | Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3) |
| Research Area | Enzymes and Kinases, Tumor Immunity, Infection Immunity, Cardiovascular Biology, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human MMP3 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P08254 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R8B8, Q3B7S0, Q6GRF8 |
| UniProt Entry Name | MMP3_HUMAN |
| Gene Symbol | MMP3 |
| GeneID | 4314 |
| OMIM | 185250 |
| HGNC | 7173 |
| KEGG | hsa:4314 |
| Ensembl | ENSG00000149968 |
| String | 9606.ENSP00000299855 |
| Enzyme Commission Number | EC 3.4.24.17 EC 3.4.24 |
| Molecular Weight | 54 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |