Mouse Prkcb Antibody
REQUEST MORE INFO
Price:
US$290.00
(Size: 80 µl)
Click on the image to see the image legend
Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-564', 'Ser-649' and 'Ser-657', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR) dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters.
Target |
Mouse Prkcb |
Clonality |
Polyclonal |
Reactivity |
Mouse |
Tested Applications |
ELISA, WB, IHC |
Host |
Rabbit |
Recommended dilutions |
WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse Prkcb. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified through a protein A column, followed by peptide affinity purification. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P68404 (UniProt,
ExPASy)
|
UniProt Secondary AC |
A0JNZ5, F2Z441, P04410, P04411 |
UniProt Entry Name |
KPCB_MOUSE |
KEGG |
mmu:18751
|
String |
10090.ENSMUSP00000070019
|
Molecular Weight |
Calculated MW: 76.8 kDa |
Buffer |
PBS containing 0.09% sodium azide. |
Specificity |
Predicted to react with Human, Rat and Cow Prkcb. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Mouse Prkcb