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Myeloid/lymphoid Or Mixed-Lineage Leukemia Protein 3 (MLL3) Antibody
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Catalogue No: abx032715
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US$50.75
(Size: 25 µl)
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Datasheet SDS
The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL3. The MLL SET domain is a histone H3 Lys4 (K4) specific methyltransferase whose activity is stimulated with acetylated H3 peptides. MLL3 maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. The deduced MLL3 4911-amino acid protein is more closely related to MLL2 than to MLL1 or MLL4. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus; a high mobility group (HMG) box, an ATPase alpha-beta signature, and a leucine zipper motif in its central region; and 2 C-terminal FY (phe-tyr) motifs and the SET domain preceded by a ZNF2 domain in its C terminus. The predicted protein also contains several putative nuclear localization motifs. Isoform II lacks ZNF1 and the PHD.
Research Articles on Myeloid/lymphoid Or Mixed-Lineage Leukemia Protein 3 (MLL3)
| Target | Myeloid/lymphoid Or Mixed-Lineage Leukemia Protein 3 (MLL3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | This MLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4345-4374 amino acids from the C-terminal region of human MLL3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q8NEZ4 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7 |
| UniProt Entry Name | KMT2C_HUMAN |
| GeneID | 58508 |
| NCBI Accession | NP_733751.2 |
| KEGG | hsa:58508 |
| String | 9606.ENSP00000262189 |
| Molecular Weight | Calculated MW: 541.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Note: This product will be discontinued once it is sold out. Please contact us for details. Shipped within 1-2 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |