PRKCE Antibody is a Rabbit Polyclonal antibody against PRKCE. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
Target
Protein Kinase C Epsilon (PRKCE)
Clonality
Polyclonal
Reactivity
Human, Mouse, Rat
Tested Applications
IHC
Host
Rabbit
Recommended dilutions
IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation
Unconjugated
Immunogen
Recombinant fusion protein corresponding to human PRKCE
Isotype
IgG
Form
Liquid
Purification
Purified by affinity chromatography.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
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