DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC) Antibody
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Catalogue No: abx011674
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.
Research Articles on DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC)
| Target | DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human PRKDC expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P78527 (UniProt, ExPASy) |
| UniProt Entry Name | PRKDC_HUMAN |
| Gene Symbol | PRKDC |
| GeneID | 5591 |
| OMIM | 600899 |
| HGNC | 9413 |
| KEGG | hsa:5591 |
| Ensembl | ENSG00000253729 |
| String | 9606.ENSP00000313420 |
| Enzyme Commission Number | EC 2.7.11.1 |
| Molecular Weight | 46.9 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |