Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) Antibody
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Catalogue No: abx011435
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Research Articles on Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1)
| Target | Raf Proto-Oncogene Serine/Threonine Protein Kinase (RAF1) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human RAF1 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04049 (UniProt, ExPASy) |
| UniProt Secondary AC | B0LPH8, B2R5N3, Q15278, Q9UC20 |
| UniProt Entry Name | RAF1_HUMAN |
| Gene Symbol | RAF1 |
| GeneID | 5894 |
| OMIM | 164760 |
| HGNC | 9829 |
| KEGG | hsa:5894 |
| Ensembl | ENSG00000132155 |
| String | 9606.ENSP00000251849 |
| Enzyme Commission Number | EC 2.7.11.1 |
| Molecular Weight | 72 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |