Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody
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Catalogue No: abx011486
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US$427.75
(Size: 100 µl)
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Datasheet SDS
ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.
Research Articles on Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)
| Target | Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) |
| Research Area | Cellular Differentiation and Adhesion |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q01973 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5VVX6, Q66K77, Q92776 |
| UniProt Entry Name | ROR1_HUMAN |
| Gene Symbol | ROR1 |
| GeneID | 4919 |
| OMIM | 602336 |
| HGNC | 10256 |
| KEGG | hsa:4919 |
| Ensembl | ENSG00000185483 |
| String | 9606.ENSP00000360120 |
| Molecular Weight | 101 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |