Ribosomal Protein S6 (RPS6) Antibody
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Catalogue No: abx031204
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPS6 is a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA.
Research Articles on Ribosomal Protein S6 (RPS6)
| Target | Ribosomal Protein S6 (RPS6) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RPS6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P62753 (UniProt, ExPASy) |
| UniProt Secondary AC | P08227, P10660, Q4VBY7, Q8N6Z7 |
| UniProt Entry Name | RS6_HUMAN |
| Gene Symbol | RPS6 |
| GeneID | 6194 |
| OMIM | 180460 |
| HGNC | 10429 |
| KEGG | hsa:6194 |
| Ensembl | ENSG00000137154 |
| String | 9606.ENSP00000369757 |
| Molecular Weight | Calculated MW: 28.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Monkey RPS6. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |