PR/SET Domain-Containing Protein 07 (SET07) Antibody

SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.

Target	PR/SET Domain-Containing Protein 07 (SET07)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 362-393 amino acids from the C-terminal region of human SET07.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NQR1 (UniProt, ExPASy)
UniProt Secondary AC	A8K9D0, Q86W83, Q8TD09
UniProt Entry Name	KMT5A_HUMAN
String	9606.ENSP00000384629
Molecular Weight	Calculated MW: 42.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PR/SET Domain-Containing Protein 07 (SET07)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue