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Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) Antibody
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Catalogue No: abx027036
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US$326.25
(Size: 80 µl)
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Datasheet SDS
The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
Research Articles on Suppressor of Variegation 3-9 Homolog 2 (SUV39H2)
| Target | Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) |
| Research Area | Epigentics, Histone Methylation |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 360-390 amino acids from the C-terminal region of human SUV39H2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9H5I1 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DRT4, Q5JSS4, Q5JSS5, Q6I9Y3, Q8ND06 |
| UniProt Entry Name | SUV92_HUMAN |
| NCBI Accession | NP_001180353.1 NP_001180354.1 NP_001180355.1 NP_001180356.1 NP_078946.1 |
| String | 9606.ENSP00000346997 |
| Molecular Weight | Calculated MW: 46.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey SUV39H2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |