E3 Ubiquitin-Protein Ligase XIAP (XIAP) Antibody
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Catalogue No: abx005234
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US$348.00
(Size: 60 µl)
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Datasheet SDS
XIAP Antibody is a Rabbit Polyclonal antibody against XIAP. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Research Articles on E3 Ubiquitin-Protein Ligase XIAP (XIAP)
| Target | E3 Ubiquitin-Protein Ligase XIAP (XIAP) |
| Research Area | Apoptosis |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human XIAP |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P98170 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DTF2, Q9NQ14 |
| UniProt Entry Name | XIAP_HUMAN |
| Gene Symbol | XIAP |
| GeneID | 331 |
| NCBI Accession | NP_001158.2 |
| KEGG | hsa:331 |
| String | 9606.ENSP00000360242 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
