Alpha-Methylacyl-CoA Racemase (AMACR) Antibody

AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids.Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue.It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia.AMACR can be used as a positive marker for PIN.Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile.Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.

Target	Alpha-Methylacyl-CoA Racemase (AMACR)
Clonality	Monoclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human AMACR expressed in E. coli.
Isotype	IgG2b
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	23600
Molecular Weight	42 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Alpha-Methylacyl-CoA Racemase (AMACR)

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